Preheat your oven to 350°F (175°C) and lightly grease a 9×13-inch baking dish. Shred all cheeses and measure your ingredients.
Bring a large pot of generously salted water to a rolling boil. Add the macaroni and cook until it's al dente—typically about 2 minutes less than the package directions suggest. Drain well, but do not rinse.
In a large, heavy-bottomed saucepan or Dutch oven, melt the ½ cup butter over medium heat. Once melted, add the flour and whisk continuously for 2-3 minutes until it forms a smooth, golden paste.
Gradually pour in the warmed milk while whisking constantly to prevent lumps from forming. Continue whisking until the mixture is smooth and begins to thicken, about 5-7 minutes. The sauce should coat the back of a spoon.
Add the salt, white pepper, nutmeg, dry mustard powder, and paprika. Whisk to incorporate all seasonings thoroughly.
Reduce heat to low and add the cheddar, Gruyère, and ¾ cup of the Parmesan cheese, reserving the remaining Parmesan for the topping. Stir until all cheese is melted and the sauce is velvety smooth. Remove from heat.
Add the drained pasta to the cheese sauce and fold gently until all pieces are evenly coated.
In a small bowl, mix the Panko breadcrumbs with the remaining Parmesan cheese and the 2 tablespoons of melted butter.
Transfer the macaroni and cheese mixture to your prepared baking dish. Sprinkle the breadcrumb mixture evenly over the top.
Bake in the preheated oven for 25-30 minutes until the top is golden brown and the edges are bubbling.
Allow the mac and cheese to rest for 5-10 minutes before serving.