Cook the elbow macaroni in generously salted water for about 2 minutes less than the package directions indicate. Drain thoroughly, but do not rinse. Return pasta to the pot and toss with a small amount of olive oil to prevent sticking.
Preheat your oven to 350°F (175°C).
In a large, heavy-bottomed saucepan, melt 4 tablespoons of butter over medium heat until it begins to foam but doesn't brown. Sprinkle in the flour and whisk continuously for 1-2 minutes until the mixture forms a smooth, blonde roux.
Gradually add the warmed milk to your roux, whisking constantly to prevent lumps. Bring the mixture to a gentle simmer, then reduce heat to medium-low. Continue cooking for 6-8 minutes, stirring regularly, until the sauce thickens enough to coat the back of a spoon.
Remove the saucepan from heat and add the dry mustard, garlic powder, cayenne (if using), salt, and pepper. Stir to incorporate.
Begin adding the cheeses one handful at a time, allowing each addition to fully melt before adding more.
Combine the cheese sauce with the cooked macaroni, folding gently until every piece is thoroughly coated. Transfer this mixture to a buttered 9x13-inch baking dish, spreading it evenly.
In a small bowl, mix together the Panko breadcrumbs, melted butter, grated Parmesan, and parsley until well combined. Sprinkle it evenly over your macaroni and cheese.
Bake uncovered for 25-30 minutes, or until the edges are bubbling and the top has turned a beautiful golden brown. For an even more spectacular finish, place under the broiler for the final 1-2 minutes, watching carefully to avoid burning.
Allow the dish to rest for 10-15 minutes before serving.